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Rap1-Mediated Activation of Extracellular Signal-Regulated Kinases by Cyclic AMP Is Dependent on the Mode of Rap1 Activation

Like other small G proteins of the Ras superfamily, Rap1 is activated by distinct guanine nucleotide exchange factors (GEFs) in response to different signals to elicit cellular responses. Activation of Rap1 by cyclic AMP (cAMP) can occur via cAMP-dependent protein kinase A (PKA)-independent and PKA-...

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Detalles Bibliográficos
Main Authors: Wang, Zhiping, Dillon, Tara J., Pokala, Viji, Mishra, Snigdha, Labudda, Kirstin, Hunter, Brian, Stork, Philip J. S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1430276/
https://ncbi.nlm.nih.gov/pubmed/16507992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.6.2130-2145.2006
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