Cyclic AMP-Mediated Inhibition of Cell Growth Requires the Small G Protein Rap1

In many normal and transformed cell types, the intracellular second messenger cyclic AMP (cAMP) blocks the effects of growth factors and serum on mitogenesis, proliferation, and cell cycle progression. cAMP exerts these growth-inhibitory effects via inhibition of the mitogen-activated protein (MAP)...

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Bibliographische Detailangaben
Hauptverfasser: Schmitt, John M., Stork, Philip J. S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC86997/
https://ncbi.nlm.nih.gov/pubmed/11340161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.11.3671-3683.2001
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