Cyclic AMP-Mediated Inhibition of Cell Growth Requires the Small G Protein Rap1

In many normal and transformed cell types, the intracellular second messenger cyclic AMP (cAMP) blocks the effects of growth factors and serum on mitogenesis, proliferation, and cell cycle progression. cAMP exerts these growth-inhibitory effects via inhibition of the mitogen-activated protein (MAP)...

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Hlavní autoři: Schmitt, John M., Stork, Philip J. S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2001
Témata:
Cell Growth and Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC86997/
https://ncbi.nlm.nih.gov/pubmed/11340161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.11.3671-3683.2001
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