Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

In melanocytes and melanoma cells, cAMP activates extracellular signal-regulated kinases (ERKs) and MEK-1 by an unknown mechanism. We demonstrate that B-Raf is activated by cAMP in melanocytes. A dominant-negative mutant of B-Raf, but not of Raf-1, blocked the cAMP-induced activation of ERK, indicat...

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Bibliografiske detaljer
Main Authors: Buscà, Roser, Abbe, Patricia, Mantoux, Fréderic, Aberdam, Edith, Peyssonnaux, Carole, Eychène, Alain, Ortonne, Jean-Paul, Ballotti, Robert
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2000
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC203360/
https://ncbi.nlm.nih.gov/pubmed/10856235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.12.2900
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