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Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes
In melanocytes and melanoma cells, cAMP activates extracellular signal-regulated kinases (ERKs) and MEK-1 by an unknown mechanism. We demonstrate that B-Raf is activated by cAMP in melanocytes. A dominant-negative mutant of B-Raf, but not of Raf-1, blocked the cAMP-induced activation of ERK, indicat...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC203360/ https://ncbi.nlm.nih.gov/pubmed/10856235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.12.2900 |
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