Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

In melanocytes and melanoma cells, cAMP activates extracellular signal-regulated kinases (ERKs) and MEK-1 by an unknown mechanism. We demonstrate that B-Raf is activated by cAMP in melanocytes. A dominant-negative mutant of B-Raf, but not of Raf-1, blocked the cAMP-induced activation of ERK, indicat...

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Detaylı Bibliyografya
Asıl Yazarlar: Buscà, Roser, Abbe, Patricia, Mantoux, Fréderic, Aberdam, Edith, Peyssonnaux, Carole, Eychène, Alain, Ortonne, Jean-Paul, Ballotti, Robert
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2000
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC203360/
https://ncbi.nlm.nih.gov/pubmed/10856235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.12.2900
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