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Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP

Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. Two small G proteins, Ras and Rap1 have been proposed to mediate this activation. Using HEK293...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Takahashi, Maho, Li, Yanping, Dillon, Tara J., Stork, Philip J. S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270487/
https://ncbi.nlm.nih.gov/pubmed/28003362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.768986
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