RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis

The nonsense mediated decay (NMD) pathway is a critical surveillance mechanism for identifying aberrant mRNA transcripts. It is unknown, however, whether the NMD system is affected by seizures in vivo and whether changes confer beneficial or maladaptive responses that influence long-term outcomes su...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Mooney, Claire M., Jimenez-Mateos, Eva M., Engel, Tobias, Mooney, Catherine, Diviney, Mairead, Venø, Morten T., Kjems, Jørgen, Farrell, Michael A., O’Brien, Donncha F., Delanty, Norman, Henshall, David C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269742/
https://ncbi.nlm.nih.gov/pubmed/28128343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41517
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge