Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

Nonsense-mediated decay (NMD) is a eukaryotic quality control mechanism that degrades mRNAs carrying premature stop codons. In mammalian cells, NMD is triggered when UPF2 bound to UPF3 on a downstream exon junction complex interacts with UPF1 bound to a stalled ribosome. We report structural studies...

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Detalhes bibliográficos
Main Authors: Clerici, Marcello, Mourão, André, Gutsche, Irina, Gehring, Niels H, Hentze, Matthias W, Kulozik, Andreas, Kadlec, Jan, Sattler, Michael, Cusack, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726699/
https://ncbi.nlm.nih.gov/pubmed/19556969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.175
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