Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2

Nonsense-mediated decay (NMD) is a eukaryotic quality control pathway, involving conserved proteins UPF1, UPF2 and UPF3b, which detects and degrades mRNAs with premature stop codons. Human UPF2 comprises three tandem MIF4G domains and a C-terminal UPF1 binding region. MIF4G-3 binds UPF3b, but the sp...

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Détails bibliographiques
Auteurs principaux: Clerici, Marcello, Deniaud, Aurélien, Boehm, Volker, Gehring, Niels H., Schaffitzel, Christiane, Cusack, Stephen
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
Sujets:
RNA
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936715/
https://ncbi.nlm.nih.gov/pubmed/24271394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1197
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