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Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2
Nonsense-mediated decay (NMD) is a eukaryotic quality control pathway, involving conserved proteins UPF1, UPF2 and UPF3b, which detects and degrades mRNAs with premature stop codons. Human UPF2 comprises three tandem MIF4G domains and a C-terminal UPF1 binding region. MIF4G-3 binds UPF3b, but the sp...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3936715/ https://ncbi.nlm.nih.gov/pubmed/24271394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1197 |
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