Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife

Nonsense-mediated mRNA decay (NMD) downmodulates mRNAs that have in-frame premature termination codons and prevents translation of potentially harmful truncated proteins from aberrant mRNAs. Two new approaches have identified physiological NMD substrates, and suggest that NMD functions as a multipur...

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Bibliographic Details
Main Authors: Neu-Yilik, Gabriele, Gehring, Niels H, Hentze, Matthias W, Kulozik, Andreas E
Format: Artigo
Language:Inglês
Published: BioMed Central 2004
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC395777/
https://ncbi.nlm.nih.gov/pubmed/15059251
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