Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife

Nonsense-mediated mRNA decay (NMD) downmodulates mRNAs that have in-frame premature termination codons and prevents translation of potentially harmful truncated proteins from aberrant mRNAs. Two new approaches have identified physiological NMD substrates, and suggest that NMD functions as a multipur...

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Main Authors: Neu-Yilik, Gabriele, Gehring, Niels H, Hentze, Matthias W, Kulozik, Andreas E
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2004
Teme:
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC395777/
https://ncbi.nlm.nih.gov/pubmed/15059251
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