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Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife

Nonsense-mediated mRNA decay (NMD) downmodulates mRNAs that have in-frame premature termination codons and prevents translation of potentially harmful truncated proteins from aberrant mRNAs. Two new approaches have identified physiological NMD substrates, and suggest that NMD functions as a multipur...

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Pubblicato in:Genome Biol
Autori principali: Neu-Yilik, Gabriele, Gehring, Niels H, Hentze, Matthias W, Kulozik, Andreas E
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2004
Soggetti:
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395777/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15059251/
https://ncbi.nlm.nih.govhttps://doi.org/10.1186/gb-2004-5-4-218
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