RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis

The nonsense mediated decay (NMD) pathway is a critical surveillance mechanism for identifying aberrant mRNA transcripts. It is unknown, however, whether the NMD system is affected by seizures in vivo and whether changes confer beneficial or maladaptive responses that influence long-term outcomes su...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Mooney, Claire M., Jimenez-Mateos, Eva M., Engel, Tobias, Mooney, Catherine, Diviney, Mairead, Venø, Morten T., Kjems, Jørgen, Farrell, Michael A., O’Brien, Donncha F., Delanty, Norman, Henshall, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269742/
https://ncbi.nlm.nih.gov/pubmed/28128343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41517
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