Prophylactic versus Therapeutic Fingolimod: Restoration of Presynaptic Defects in Mice Suffering from Experimental Autoimmune Encephalomyelitis

Fingolimod, the first oral, disease-modifying therapy for MS, has been recently proposed to modulate glutamate transmission in the central nervous system (CNS) of mice suffering from Experimental Autoimmune Encephalomyelitis (EAE) and in MS patients. Our study aims at investigating whether oral fing...

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Detalles Bibliográficos
Publicado en:PLoS One
Autores principales: Bonfiglio, Tommaso, Olivero, Guendalina, Merega, Elisa, Di Prisco, Silvia, Padolecchia, Cristina, Grilli, Massimo, Milanese, Marco, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Bonanno, Giambattista, Marchi, Mario, Pittaluga, Anna
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5268435/
https://ncbi.nlm.nih.gov/pubmed/28125677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170825
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