Prophylactic versus Therapeutic Fingolimod: Restoration of Presynaptic Defects in Mice Suffering from Experimental Autoimmune Encephalomyelitis

Fingolimod, the first oral, disease-modifying therapy for MS, has been recently proposed to modulate glutamate transmission in the central nervous system (CNS) of mice suffering from Experimental Autoimmune Encephalomyelitis (EAE) and in MS patients. Our study aims at investigating whether oral fing...

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Udgivet i:PLoS One
Main Authors: Bonfiglio, Tommaso, Olivero, Guendalina, Merega, Elisa, Di Prisco, Silvia, Padolecchia, Cristina, Grilli, Massimo, Milanese, Marco, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Bonanno, Giambattista, Marchi, Mario, Pittaluga, Anna
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5268435/
https://ncbi.nlm.nih.gov/pubmed/28125677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170825
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