Prophylactic versus Therapeutic Fingolimod: Restoration of Presynaptic Defects in Mice Suffering from Experimental Autoimmune Encephalomyelitis

Fingolimod, the first oral, disease-modifying therapy for MS, has been recently proposed to modulate glutamate transmission in the central nervous system (CNS) of mice suffering from Experimental Autoimmune Encephalomyelitis (EAE) and in MS patients. Our study aims at investigating whether oral fing...

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Veröffentlicht in:PLoS One
Hauptverfasser: Bonfiglio, Tommaso, Olivero, Guendalina, Merega, Elisa, Di Prisco, Silvia, Padolecchia, Cristina, Grilli, Massimo, Milanese, Marco, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Bonanno, Giambattista, Marchi, Mario, Pittaluga, Anna
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5268435/
https://ncbi.nlm.nih.gov/pubmed/28125677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170825
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