Acute desipramine restores presynaptic cortical defects in murine experimental autoimmune encephalomyelitis by suppressing central CCL5 overproduction

BACKGROUND AND PURPOSE: Altered glutamate exocytosis and cAMP production in cortical terminals of experimental autoimmune encephalomyelitis (EAE) mice occur at the early stage of disease (13 days post-immunization, d.p.i.). Neuronal defects were paralleled by overexpression of the central chemokine...

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Dettagli Bibliografici
Autori principali: Di Prisco, Silvia, Merega, Elisa, Lanfranco, Massimiliano, Casazza, Simona, Uccelli, Antonio, Pittaluga, Anna
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2014
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3997283/
https://ncbi.nlm.nih.gov/pubmed/24528439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12631
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