Prophylactic versus Therapeutic Fingolimod: Restoration of Presynaptic Defects in Mice Suffering from Experimental Autoimmune Encephalomyelitis

Fingolimod, the first oral, disease-modifying therapy for MS, has been recently proposed to modulate glutamate transmission in the central nervous system (CNS) of mice suffering from Experimental Autoimmune Encephalomyelitis (EAE) and in MS patients. Our study aims at investigating whether oral fing...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bonfiglio, Tommaso, Olivero, Guendalina, Merega, Elisa, Di Prisco, Silvia, Padolecchia, Cristina, Grilli, Massimo, Milanese, Marco, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Bonanno, Giambattista, Marchi, Mario, Pittaluga, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5268435/
https://ncbi.nlm.nih.gov/pubmed/28125677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170825
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