Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy

Neurodegenerative disorders such as Parkinson’s Disease (PD), PD dementia (PDD) and Dementia with Lewy bodies (DLB) are characterized by progressive accumulation of α-synuclein (α-syn) in neurons. Recent studies have proposed that neuron-to-neuron propagation of α-syn plays a role in the pathogenesi...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Spencer, Brian, Valera, Elvira, Rockenstein, Edward, Overk, Cassia, Mante, Michael, Adame, Anthony, Zago, Wagner, Seubert, Peter, Barbour, Robin, Schenk, Dale, Games, Dora, Rissman, Robert A., Masliah, Eliezer
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5237270/
https://ncbi.nlm.nih.gov/pubmed/28086964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0410-8
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