Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy

Disorders with progressive accumulation of α-synuclein (α-syn) are a common cause of dementia and parkinsonism in the aging population. Accumulation and propagation of α-syn play a role in the pathogenesis of these disorders. Previous studies have shown that immunization with antibodies that recogni...

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Bibliographische Detailangaben
Veröffentlicht in:Neurobiol Dis
Hauptverfasser: El-Agnaf, Omar, Overk, Cassia, Rockenstein, Edward, Mante, Michael, Florio, Jazmin, Adame, Anthony, Vaikath, Nishant, Majbour, Nour, Lee, Seung-Jae, Kim, Changyoun, Masliah, Eliezer, Rissman, Robert A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954414/
https://ncbi.nlm.nih.gov/pubmed/28476636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2017.05.002
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