Alpha-synuclein stimulation of astrocytes: Potential role for neuroinflammation and neuroprotection

por Lee, He-Jin, Kim, Changyoun, Lee, Seung-Jae
Publicado 2010

Targeting Microglial and Neuronal Toll-like Receptor 2 in Synucleinopathies

por Kwon, Somin, Iba, Michiyo, Masliah, Eliezer, Kim, Changyoun
Publicado en Exp Neurobiol (2019)

Immunotherapies for Aging-Related Neurodegenerative Diseases—Emerging Perspectives and New Targets

por Kwon, Somin, Iba, Michiyo, Kim, Changyoun, Masliah, Eliezer
Publicado en Neurotherapeutics (2020)

Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2

por Kim, Changyoun, Lee, He-Jin, Masliah, Eliezer, Lee, Seung-Jae
Publicado en Exp Neurobiol (2016)

β1-integrin-dependent migration of microglia in response to neuron-released α-synuclein

por Kim, Changyoun, Cho, Eun-Deok, Kim, Hyung-Koo, You, Sungyong, Lee, He-Jin, Hwang, Daehee, Lee, Seung-Jae
Publicado 2014

Role of Alterations in Protein Kinase p38γ in the Pathogenesis of the Synaptic Pathology in Dementia With Lewy Bodies and α-Synuclein Transgenic Models

por Iba, Michiyo, Kim, Changyoun, Florio, Jazmin, Mante, Michael, Adame, Anthony, Rockenstein, Edward, Kwon, Somin, Rissman, Robert, Masliah, Eliezer
Publicado en Front Neurosci (2020)

α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease

por Spencer, Brian, Kim, Changyoun, Gonzalez, Tania, Bisquertt, Alejandro, Patrick, Christina, Rockenstein, Edward, Adame, Anthony, Lee, Seung-Jae, Desplats, Paula, Masliah, Eliezer
Publicado en Hum Mol Genet (2016)

Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models

por Iba, Michiyo, Kim, Changyoun, Sallin, Michelle, Kwon, Somin, Verma, Anjali, Overk, Cassia, Rissman, Robert A., Sen, Ranjan, Sen, Jyoti Misra, Masliah, Eliezer
Publicado en J Neuroinflammation (2020)

A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt...

por Lee, Young Han, Jeon, Seung-Hyun, Kim, Se Hyun, Kim, Changyoun, Lee, Seung-Jae, Koh, Dongsoo, Lim, Yoongho, Ha, Kyooseob, Shin, Soon Young
Publicado 2012

Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy

por Kim, Changyoun, Rockenstein, Edward, Spencer, Brian, Kim, Hyung-Koo, Adame, Anthony, Trejo, Margarita, Stafa, Klodjan, Lee, He-Jin, Lee, Seung-Jae, Masliah, Eliezer
Publicado en Cell Rep (2015)

Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease

por Spencer, Brian, Trinh, Ivy, Rockenstein, Edward, Mante, Michael, Florio, Jazmin, Adame, Anthony, El-Agnaf, Omar MA, Kim, Changyoun, Masliah, Eliezer, Rissman, Robert A.
Publicado en Neurobiol Dis (2019)

Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies

por Rockenstein, Edward, Ostroff, Gary, Dikengil, Fusun, Rus, Florentina, Mante, Michael, Florio, Jazmin, Adame, Anthony, Trinh, Ivy, Kim, Changyoun, Overk, Cassia, Masliah, Eliezer, Rissman, Robert A.
Publicado en J Neurosci (2018)

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

por Kim, Changyoun, Ho, Dong-Hwan, Suk, Ji-Eun, You, Sungyong, Michael, Sarah, Kang, Junghee, Lee, Sung Joong, Masliah, Eliezer, Hwang, Daehee, Lee, He-Jin, Lee, Seung-Jae
Publicado 2013

Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy

por El-Agnaf, Omar, Overk, Cassia, Rockenstein, Edward, Mante, Michael, Florio, Jazmin, Adame, Anthony, Vaikath, Nishant, Majbour, Nour, Lee, Seung-Jae, Kim, Changyoun, Masliah, Eliezer, Rissman, Robert A.
Publicado en Neurobiol Dis (2017)

Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells

por Kim, Changyoun, Kwon, Somin, Iba, Michiyo, Spencer, Brian, Rockenstein, Edward, Mante, Michael, Adame, Anthony, Shin, Soo Jean, Fields, Jerel A., Rissman, Robert A., Lee, Seung-Jae, Masliah, Eliezer
Publicado en Exp Mol Med (2021)

Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson’s disease

por Kim, Changyoun, Ojo-Amaize, Emmanuel, Spencer, Brian, Rockenstein, Edward, Mante, Michael, Desplats, Paula, Wrasidlo, Wolf, Adame, Anthony, Nchekwube, Emeka, Oyemade, Olusola, Okogun, Joseph, Chan, Michael, Cottam, Howard, Masliah, Eliezer
Publicado en J Neuroinflammation (2015)

Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

por Kim, Changyoun, Spencer, Brian, Rockenstein, Edward, Yamakado, Hodaka, Mante, Michael, Adame, Anthony, Fields, Jerel Adam, Masliah, Deborah, Iba, Michiyo, Lee, He-Jin, Rissman, Robert A., Lee, Seung-Jae, Masliah, Eliezer
Publicado en Mol Neurodegener (2018)

Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson’s disease

por Rockenstein, Edward, Clarke, Jennifer, Viel, Catherine, Panarello, Nicholas, Treleaven, Christopher M., Kim, Changyoun, Spencer, Brian, Adame, Anthony, Park, Hyejung, Dodge, James C., Cheng, Seng H., Shihabuddin, Lamya S., Masliah, E., Sardi, S. Pablo
Publicado en Hum Mol Genet (2016)

Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in a dementia with Lewy bodies–like model

por Mandler, Markus, Rockenstein, Edward, Overk, Cassia, Mante, Michael, Florio, Jazmin, Adame, Anthony, Kim, Changyoun, Santic, Radmila, Schneeberger, Achim, Mattner, Frank, Schmidhuber, SAbine, GalAbova, Gergana, Spencer, Brian, Masliah, Eliezer, Rissman, Robert A.
Publicado en Alzheimers Dement (2019)

HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-Associated Neurocognitive Disorders

por Fields, Jerel Adam, Serger, Elisabeth, Campos, Sofia, Divakaruni, Ajit S., Kim, Changyoun, Smith, Kendall, Trejo, Margarita, Adame, Anthony, Spencer, Brian, Rockenstein, Edward, Murphy, Anne N., Ellis, Ronald J., Letendre, Scott, Grant, Igor, Masliah, Eliezer
Publicado en Neurobiol Dis (2015)