Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson’s disease

Mutations in GBA1, the gene encoding glucocerebrosidase, are associated with an enhanced risk of developing synucleinopathies such as Parkinson’s disease (PD) and dementia with Lewy bodies. A higher prevalence and increased severity of motor and non-motor symptoms is observed in PD patients harborin...

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Publié dans:Hum Mol Genet
Auteurs principaux: Rockenstein, Edward, Clarke, Jennifer, Viel, Catherine, Panarello, Nicholas, Treleaven, Christopher M., Kim, Changyoun, Spencer, Brian, Adame, Anthony, Park, Hyejung, Dodge, James C., Cheng, Seng H., Shihabuddin, Lamya S., Masliah, E., Sardi, S. Pablo
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2016
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5181635/
https://ncbi.nlm.nih.gov/pubmed/27126635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw124
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