Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells

Synucleinopathies are age-related neurological disorders characterized by the progressive deposition of α-synuclein (α-syn) aggregates and include Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Although cell-to-cell α-syn transmission is thought to play a key role in the spread of α-s...

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Vydáno v:Exp Mol Med
Hlavní autoři: Kim, Changyoun, Kwon, Somin, Iba, Michiyo, Spencer, Brian, Rockenstein, Edward, Mante, Michael, Adame, Anthony, Shin, Soo Jean, Fields, Jerel A., Rissman, Robert A., Lee, Seung-Jae, Masliah, Eliezer
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080790/
https://ncbi.nlm.nih.gov/pubmed/33594256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-021-00562-6
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