Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

BACKGROUND: Synucleinopathies of the aging population are an heterogeneous group of neurological disorders that includes Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) and are characterized by the progressive accumulation of α-synuclein in neuronal and glial cells. Toll-like receptor 2...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Mol Neurodegener
Päätekijät: Kim, Changyoun, Spencer, Brian, Rockenstein, Edward, Yamakado, Hodaka, Mante, Michael, Adame, Anthony, Fields, Jerel Adam, Masliah, Deborah, Iba, Michiyo, Lee, He-Jin, Rissman, Robert A., Lee, Seung-Jae, Masliah, Eliezer
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2018
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085656/
https://ncbi.nlm.nih.gov/pubmed/30092810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0276-2
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