Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model

Alzheimer's disease (AD) is characterized by the progressive accumulation of amyloid β (Aβ) and microtubule associate protein tau, leading to the selective degeneration of neurons in the neocortex, limbic system, and nucleus basalis, among others. Recent studies have shown that α-synuclein (α-s...

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Udgivet i:J Neurosci
Main Authors: Spencer, Brian, Desplats, Paula A., Overk, Cassia R., Valera-Martin, Elvira, Rissman, Robert A., Wu, Chengbiao, Mante, Michael, Adame, Anthony, Florio, Jazmin, Rockenstein, Edward, Masliah, Eliezer
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961781/
https://ncbi.nlm.nih.gov/pubmed/27466341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0775-16.2016
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