CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1

Tumour metastasis, the spread of cancer cells from the original tumour site followed by growth of secondary tumours at distant organs, is the primary cause of cancer-related deaths and remains poorly understood. Here we demonstrate that inhibition of CDK4/6 blocks breast tumour metastasis in the tri...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Liu, Tongzheng, Yu, Jia, Deng, Min, Yin, Yujiao, Zhang, Haoxing, Luo, Kuntian, Qin, Bo, Li, Yunhui, Wu, Chenming, Ren, Tao, Han, Yang, Yin, Peng, Kim, JungJin, Lee, SeungBaek, Lin, Jing, Zhang, Lizhi, Zhang, Jun, Nowsheen, Somaira, Wang, Liewei, Boughey, Judy, Goetz, Matthew P., Yuan, Jian, Lou, Zhenkun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5228031/
https://ncbi.nlm.nih.gov/pubmed/28067227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13923
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