A phosphorylation–deubiquitination cascade regulates the BRCA2–RAD51 axis in homologous recombination

Homologous recombination (HR) is one of the major DNA double-strand break (DSB) repair pathways in mammalian cells. Defects in HR trigger genomic instability and result in cancer predisposition. The defining step of HR is homologous strand exchange directed by the protein RAD51, which is recruited t...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Luo, Kuntian, Li, Lei, Li, Yunhui, Wu, Chenming, Yin, Yujiao, Chen, Yuping, Deng, Min, Nowsheen, Somaira, Yuan, Jian, Lou, Zhenkun
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5204351/
https://ncbi.nlm.nih.gov/pubmed/27941124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.289439.116
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