A phosphorylation–deubiquitination cascade regulates the BRCA2–RAD51 axis in homologous recombination

Homologous recombination (HR) is one of the major DNA double-strand break (DSB) repair pathways in mammalian cells. Defects in HR trigger genomic instability and result in cancer predisposition. The defining step of HR is homologous strand exchange directed by the protein RAD51, which is recruited t...

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Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Luo, Kuntian, Li, Lei, Li, Yunhui, Wu, Chenming, Yin, Yujiao, Chen, Yuping, Deng, Min, Nowsheen, Somaira, Yuan, Jian, Lou, Zhenkun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2016
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5204351/
https://ncbi.nlm.nih.gov/pubmed/27941124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.289439.116
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