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Structural and mutational analysis of the nonribosomal peptide synthetase heterocyclization domain provides insight into catalysis
Nonribosomal peptide synthetases (NRPSs) are a family of multidomain, multimodule enzymes that synthesize structurally and functionally diverse peptides, many of which are of great therapeutic or commercial value. The central chemical step of peptide synthesis is amide bond formation, which is typic...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5224394/ https://ncbi.nlm.nih.gov/pubmed/27994138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614191114 |
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