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Structural and mutational analysis of the nonribosomal peptide synthetase heterocyclization domain provides insight into catalysis
Nonribosomal peptide synthetases (NRPSs) are a family of multidomain, multimodule enzymes that synthesize structurally and functionally diverse peptides, many of which are of great therapeutic or commercial value. The central chemical step of peptide synthesis is amide bond formation, which is typic...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5224394/ https://ncbi.nlm.nih.gov/pubmed/27994138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614191114 |
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