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Structural and mutational analysis of the nonribosomal peptide synthetase heterocyclization domain provides insight into catalysis

Nonribosomal peptide synthetases (NRPSs) are a family of multidomain, multimodule enzymes that synthesize structurally and functionally diverse peptides, many of which are of great therapeutic or commercial value. The central chemical step of peptide synthesis is amide bond formation, which is typic...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Bloudoff, Kristjan, Fage, Christopher D., Marahiel, Mohamed A., Schmeing, T. Martin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224394/
https://ncbi.nlm.nih.gov/pubmed/27994138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614191114
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