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Structural and mutational analysis of the nonribosomal peptide synthetase heterocyclization domain provides insight into catalysis

Nonribosomal peptide synthetases (NRPSs) are a family of multidomain, multimodule enzymes that synthesize structurally and functionally diverse peptides, many of which are of great therapeutic or commercial value. The central chemical step of peptide synthesis is amide bond formation, which is typic...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Bloudoff, Kristjan, Fage, Christopher D., Marahiel, Mohamed A., Schmeing, T. Martin
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224394/
https://ncbi.nlm.nih.gov/pubmed/27994138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614191114
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