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Structural and mutational analysis of the nonribosomal peptide synthetase heterocyclization domain provides insight into catalysis

Nonribosomal peptide synthetases (NRPSs) are a family of multidomain, multimodule enzymes that synthesize structurally and functionally diverse peptides, many of which are of great therapeutic or commercial value. The central chemical step of peptide synthesis is amide bond formation, which is typic...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Bloudoff, Kristjan, Fage, Christopher D., Marahiel, Mohamed A., Schmeing, T. Martin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224394/
https://ncbi.nlm.nih.gov/pubmed/27994138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614191114
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