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Crystal structures of the first condensation domain of CDA synthetase suggest conformational changes during the synthetic cycle of nonribosomal peptide synthetases

Nonribosomal peptide synthetases (NRPS) are large modular macromolecular machines that produce small peptide molecules with wide-ranging biological activities, such as antibiotics and green chemicals. The condensation (C) domain is responsible for amide bond formation, the central chemical step in n...

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Pubblicato in:J Mol Biol
Autori principali: Bloudoff, Kristjan, Rodionov, Dmitry, Schmeing, T. Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318696/
https://ncbi.nlm.nih.gov/pubmed/23756159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.06.003
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