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Structures of Two Distinct Conformations of holo-Nonribosomal Peptide Synthetases

Many important natural products are produced by multidomain nonribosomal peptide synthetases (NRPSs)(1–4). During synthesis, intermediates are covalently bound to integrated carrier domains and transported to neighboring catalytic domains in an assembly line fashion(5). Understanding the structural...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Drake, Eric J., Miller, Bradley R., Shi, Ce, Tarrasch, Jeffrey T., Sundlov, Jesse A., Allen, C. Leigh, Skiniotis, Georgios, Aldrich, Courtney C., Gulick, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843164/
https://ncbi.nlm.nih.gov/pubmed/26762461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16163
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