Structures of Two Distinct Conformations of holo-Nonribosomal Peptide Synthetases

Many important natural products are produced by multidomain nonribosomal peptide synthetases (NRPSs)(1–4). During synthesis, intermediates are covalently bound to integrated carrier domains and transported to neighboring catalytic domains in an assembly line fashion(5). Understanding the structural...

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Bibliografske podrobnosti
izdano v:Nature
Main Authors: Drake, Eric J., Miller, Bradley R., Shi, Ce, Tarrasch, Jeffrey T., Sundlov, Jesse A., Allen, C. Leigh, Skiniotis, Georgios, Aldrich, Courtney C., Gulick, Andrew M.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843164/
https://ncbi.nlm.nih.gov/pubmed/26762461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16163
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