Structures of Two Distinct Conformations of holo-Nonribosomal Peptide Synthetases

Many important natural products are produced by multidomain nonribosomal peptide synthetases (NRPSs)(1–4). During synthesis, intermediates are covalently bound to integrated carrier domains and transported to neighboring catalytic domains in an assembly line fashion(5). Understanding the structural...

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Detaylı Bibliyografya
Yayımlandı:Nature
Asıl Yazarlar: Drake, Eric J., Miller, Bradley R., Shi, Ce, Tarrasch, Jeffrey T., Sundlov, Jesse A., Allen, C. Leigh, Skiniotis, Georgios, Aldrich, Courtney C., Gulick, Andrew M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843164/
https://ncbi.nlm.nih.gov/pubmed/26762461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16163
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