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Design, Synthesis and Biophysical Evaluation of Mechanism-Based Probes for Condensation Domains of Nonribosomal Peptide Synthetases

Nonribosomal peptide synthetases (NRPSs) are remarkable modular enzymes that synthesize peptide natural products. The condensation (C) domain catalyzes the key amide bond-forming reaction, but structural characterization with bound donor and acceptor substrates has proven elusive. We describe the ch...

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Publicado en:ACS Chem Biol
Main Authors: Shi, Ce, Miller, Bradley R., Alexander, Evan M., Gulick, Andrew, Aldrich, Courtney
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368817/
https://ncbi.nlm.nih.gov/pubmed/32568518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00411
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