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Design, Synthesis and Biophysical Evaluation of Mechanism-Based Probes for Condensation Domains of Nonribosomal Peptide Synthetases
Nonribosomal peptide synthetases (NRPSs) are remarkable modular enzymes that synthesize peptide natural products. The condensation (C) domain catalyzes the key amide bond-forming reaction, but structural characterization with bound donor and acceptor substrates has proven elusive. We describe the ch...
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| Izdano u: | ACS Chem Biol |
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| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7368817/ https://ncbi.nlm.nih.gov/pubmed/32568518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00411 |
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