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Specific disulfide cross-linking to constrict the mobile carrier domain of nonribosomal peptide synthetases

Nonribosomal peptide synthetases are large, multi-domain enzymes that produce peptide molecules with important biological activity such as antibiotic, antiviral, anti-tumor, siderophore and immunosuppressant action. The adenylation (A) domain catalyzes two reactions in the biosynthetic pathway. In t...

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Detalhes bibliográficos
Publicado no:Protein Eng Des Sel
Main Authors: Tarry, Michael J., Schmeing, T. Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502403/
https://ncbi.nlm.nih.gov/pubmed/25713404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzv009
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