Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics

Peptide deformylase activity was thought to be limited to ribosomal protein synthesis in prokaryotes, where new peptides are initiated with an N-formylated methionine. We describe here a new human peptide deformylase (Homo sapiens PDF, or HsPDF) that is localized to the mitochondria. HsPDF is capabl...

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Detalhes bibliográficos
Main Authors: Lee, Mona D., She, Yuhong, Soskis, Michael J., Borella, Christopher P., Gardner, Jeffrey R., Hayes, Paula A., Dy, Benzon M., Heaney, Mark L., Philips, Mark R., Bornmann, William G., Sirotnak, Francis M., Scheinberg, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC522256/
https://ncbi.nlm.nih.gov/pubmed/15489958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200422269
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