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Subinhibitory Concentrations of the Deformylase Inhibitor Actinonin Increase Bacterial Release of Neutrophil-Activating Peptides: a New Approach to Antimicrobial Chemotherapy

Bacterial protein synthesis starts with a formylated methionine residue, and this residue is sequentially cleaved away by a unique peptide deformylase (PDF) and a methionine aminopeptidase to generate mature proteins. The formylation-deformylation of proteins is a unique hallmark of bacterial metabo...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Fu, Huamei, Dahlgren, Claes, Bylund, Johan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
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Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166101/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12878517/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.8.2545-2550.2003
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