Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers

Inhibition of human mitochondrial peptide deformylase (HsPDF) depolarizes the mitochondrial membrane, reduces mitochondrial protein translation and causes apoptosis in Burkitt's lymphoma. We showed that HsPDF mRNA and protein levels were overexpressed in cancer cells and primary acute myeloid l...

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Hlavní autoři: Sheth, A, Escobar-Alvarez, S, Gardner, J, Ran, L, Heaney, M L, Scheinberg, D A
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973238/
https://ncbi.nlm.nih.gov/pubmed/24675470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.112
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