Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers

Inhibition of human mitochondrial peptide deformylase (HsPDF) depolarizes the mitochondrial membrane, reduces mitochondrial protein translation and causes apoptosis in Burkitt's lymphoma. We showed that HsPDF mRNA and protein levels were overexpressed in cancer cells and primary acute myeloid l...

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Detalhes bibliográficos
Main Authors: Sheth, A, Escobar-Alvarez, S, Gardner, J, Ran, L, Heaney, M L, Scheinberg, D A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973238/
https://ncbi.nlm.nih.gov/pubmed/24675470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.112
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