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Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target
Peptide deformylase proteins (PDFs) participate in the N-terminal methionine excision pathway of newly synthesized peptides. We show that the human PDF (HsPDF) can deformylate its putative substrates derived from mitochondrial DNA-encoded proteins. The first structural model of a mammalian PDF (1.7...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2782631/ https://ncbi.nlm.nih.gov/pubmed/19236878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.02.032 |
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