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Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase

Selective inhibitors of human peptide deformylase (HsPDF) are predicted to constitute a new class of antitumor agents. We report the identification of benzofuran-4,5-diones as the first known selective HsPDF inhibitors and we describe their selectivity profile in a panel of metalloproteases. We char...

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Detalhes bibliográficos
Main Authors: Antczak, Christophe, Shum, David, Bassit, Bhramdeo, Frattini, Mark G., Li, Yueming, de Stanchina, Elisa, Scheinberg, David A., Djaballah, Hakim
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139024/
https://ncbi.nlm.nih.gov/pubmed/21719286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.05.129
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