Peptide deformylase inhibitor actinonin reduces celastrol’s HSP70 induction while synergizing proliferation inhibition in tumor cells

BACKGROUND: Celastrol is a promising anti-tumor agent, yet it also elevates heat shock proteins (HSPs), especially HSP70, this effect believed to reduce its anti-tumor effects. Concurrent use of siRNA to increase celastrol’s anti-tumor effects through HSP70 interference has been reported, but becaus...

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Detalhes bibliográficos
Main Authors: Peng, Bin, Zhang, Xue, Cao, Fanfan, Wang, Ying, Xu, Limin, Cao, Lu, Yang, Chunxin, Li, Maoquan, Uzan, Georges, Zhang, Denghai
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975845/
https://ncbi.nlm.nih.gov/pubmed/24589236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-146
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