Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites

BACKGROUND: Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is a key enzyme for the metabolism of many toxic aldehydes such as acetaldehyde, derived from alcohol drinking, and 4HNE, an oxidative stress-derived lipid peroxidation aldehyde. Post-translational enhancement of ALDH2 activity can be achiev...

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Veröffentlicht in:J Biomed Sci
Hauptverfasser: Nene, Aishwarya, Chen, Che-Hong, Disatnik, Marie-Hélène, Cruz, Leslie, Mochly-Rosen, Daria
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217657/
https://ncbi.nlm.nih.gov/pubmed/28056995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-016-0312-x
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