Protein disulfide isomerase inhibition blocks thrombin generation in humans by interfering with platelet factor V activation

BACKGROUND: Protein disulfide isomerase (PDI) is required for thrombus formation. We previously demonstrated that glycosylated quercetin flavonoids such as isoquercetin inhibit PDI activity and thrombus formation in animal models, but whether extracellular PDI represents a viable anticoagulant targe...

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Detaylı Bibliyografya
Yayımlandı:JCI Insight
Asıl Yazarlar: Stopa, Jack D., Neuberg, Donna, Puligandla, Maneka, Furie, Bruce, Flaumenhaft, Robert, Zwicker, Jeffrey I.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2017
Konular:
Clinical Medicine
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214567/
https://ncbi.nlm.nih.gov/pubmed/28097231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89373
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