Kinetic-based trapping by intervening sequence variants of the active sites of protein-disulfide isomerase identifies platelet protein substrates

Thiol isomerases such as protein-disulfide isomerase (PDI) direct disulfide rearrangements required for proper folding of nascent proteins synthesized in the endoplasmic reticulum. Identifying PDI substrates is challenging because PDI catalyzes conformational changes that cannot be easily monitored...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Stopa, Jack D., Baker, Katherine M., Grover, Steven P., Flaumenhaft, Robert, Furie, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454092/
https://ncbi.nlm.nih.gov/pubmed/28364042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.771832
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