Kinetic-based trapping by intervening sequence variants of the active sites of protein-disulfide isomerase identifies platelet protein substrates

Thiol isomerases such as protein-disulfide isomerase (PDI) direct disulfide rearrangements required for proper folding of nascent proteins synthesized in the endoplasmic reticulum. Identifying PDI substrates is challenging because PDI catalyzes conformational changes that cannot be easily monitored...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Stopa, Jack D., Baker, Katherine M., Grover, Steven P., Flaumenhaft, Robert, Furie, Bruce
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2017
Sujets:
Enzymology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454092/
https://ncbi.nlm.nih.gov/pubmed/28364042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.771832
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