Targeting protein disulfide isomerase with the flavonoid isoquercetin to improve hypercoagulability in advanced cancer

BACKGROUND. Protein disulfide isomerase (PDI) is a thiol isomerase secreted by vascular cells that is required for thrombus formation. Quercetin flavonoids inhibit PDI activity and block platelet accumulation and fibrin generation at the site of a vascular injury in mouse models, but the clinical ef...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Zwicker, Jeffrey I., Schlechter, Benjamin L., Stopa, Jack D., Liebman, Howard A., Aggarwal, Anita, Puligandla, Maneka, Caughey, Thomas, Bauer, Kenneth A., Kuemmerle, Nancy, Wong, Ellice, Wun, Ted, McLaughlin, Marilyn, Hidalgo, Manuel, Neuberg, Donna, Furie, Bruce, Flaumenhaft, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478409/
https://ncbi.nlm.nih.gov/pubmed/30652973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125851
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