Targeting protein disulfide isomerase with the flavonoid isoquercetin to improve hypercoagulability in advanced cancer

BACKGROUND. Protein disulfide isomerase (PDI) is a thiol isomerase secreted by vascular cells that is required for thrombus formation. Quercetin flavonoids inhibit PDI activity and block platelet accumulation and fibrin generation at the site of a vascular injury in mouse models, but the clinical ef...

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Detaylı Bibliyografya
Yayımlandı:JCI Insight
Asıl Yazarlar: Zwicker, Jeffrey I., Schlechter, Benjamin L., Stopa, Jack D., Liebman, Howard A., Aggarwal, Anita, Puligandla, Maneka, Caughey, Thomas, Bauer, Kenneth A., Kuemmerle, Nancy, Wong, Ellice, Wun, Ted, McLaughlin, Marilyn, Hidalgo, Manuel, Neuberg, Donna, Furie, Bruce, Flaumenhaft, Robert
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2019
Konular:
Clinical Medicine
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478409/
https://ncbi.nlm.nih.gov/pubmed/30652973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125851
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