Targeting protein disulfide isomerase with the flavonoid isoquercetin to improve hypercoagulability in advanced cancer

BACKGROUND. Protein disulfide isomerase (PDI) is a thiol isomerase secreted by vascular cells that is required for thrombus formation. Quercetin flavonoids inhibit PDI activity and block platelet accumulation and fibrin generation at the site of a vascular injury in mouse models, but the clinical ef...

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發表在:JCI Insight
Main Authors: Zwicker, Jeffrey I., Schlechter, Benjamin L., Stopa, Jack D., Liebman, Howard A., Aggarwal, Anita, Puligandla, Maneka, Caughey, Thomas, Bauer, Kenneth A., Kuemmerle, Nancy, Wong, Ellice, Wun, Ted, McLaughlin, Marilyn, Hidalgo, Manuel, Neuberg, Donna, Furie, Bruce, Flaumenhaft, Robert
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2019
主題:
Clinical Medicine
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478409/
https://ncbi.nlm.nih.gov/pubmed/30652973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125851
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