Targeting protein disulfide isomerase with the flavonoid isoquercetin to improve hypercoagulability in advanced cancer

BACKGROUND. Protein disulfide isomerase (PDI) is a thiol isomerase secreted by vascular cells that is required for thrombus formation. Quercetin flavonoids inhibit PDI activity and block platelet accumulation and fibrin generation at the site of a vascular injury in mouse models, but the clinical ef...

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Vydáno v:JCI Insight
Hlavní autoři: Zwicker, Jeffrey I., Schlechter, Benjamin L., Stopa, Jack D., Liebman, Howard A., Aggarwal, Anita, Puligandla, Maneka, Caughey, Thomas, Bauer, Kenneth A., Kuemmerle, Nancy, Wong, Ellice, Wun, Ted, McLaughlin, Marilyn, Hidalgo, Manuel, Neuberg, Donna, Furie, Bruce, Flaumenhaft, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Clinical Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478409/
https://ncbi.nlm.nih.gov/pubmed/30652973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125851
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