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Protein disulfide isomerase inhibition blocks thrombin generation in humans by interfering with platelet factor V activation
BACKGROUND: Protein disulfide isomerase (PDI) is required for thrombus formation. We previously demonstrated that glycosylated quercetin flavonoids such as isoquercetin inhibit PDI activity and thrombus formation in animal models, but whether extracellular PDI represents a viable anticoagulant targe...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5214567/ https://ncbi.nlm.nih.gov/pubmed/28097231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89373 |
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