Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination

Glioblastoma is the most lethal brain tumor and harbors glioma stem cells (GSCs) with potent tumorigenic capacity. The function of GSCs in tumor propagation is maintained by several core transcriptional regulators including c-Myc. c-Myc protein is tightly regulated by posttranslational modification....

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Fang, Xiaoguang, Zhou, Wenchao, Wu, Qiulian, Huang, Zhi, Shi, Yu, Yang, Kailin, Chen, Cong, Xie, Qi, Mack, Stephen C., Wang, Xiuxing, Carcaboso, Angel M., Sloan, Andrew E., Ouyang, Gaoliang, McLendon, Roger E., Bian, Xiu-wu, Rich, Jeremy N., Bao, Shideng
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206492/
https://ncbi.nlm.nih.gov/pubmed/27923907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151673
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker