Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination

Glioblastoma is the most lethal brain tumor and harbors glioma stem cells (GSCs) with potent tumorigenic capacity. The function of GSCs in tumor propagation is maintained by several core transcriptional regulators including c-Myc. c-Myc protein is tightly regulated by posttranslational modification....

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Fang, Xiaoguang, Zhou, Wenchao, Wu, Qiulian, Huang, Zhi, Shi, Yu, Yang, Kailin, Chen, Cong, Xie, Qi, Mack, Stephen C., Wang, Xiuxing, Carcaboso, Angel M., Sloan, Andrew E., Ouyang, Gaoliang, McLendon, Roger E., Bian, Xiu-wu, Rich, Jeremy N., Bao, Shideng
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206492/
https://ncbi.nlm.nih.gov/pubmed/27923907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151673
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