Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination

Glioblastoma is the most lethal brain tumor and harbors glioma stem cells (GSCs) with potent tumorigenic capacity. The function of GSCs in tumor propagation is maintained by several core transcriptional regulators including c-Myc. c-Myc protein is tightly regulated by posttranslational modification....

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Exp Med
Päätekijät: Fang, Xiaoguang, Zhou, Wenchao, Wu, Qiulian, Huang, Zhi, Shi, Yu, Yang, Kailin, Chen, Cong, Xie, Qi, Mack, Stephen C., Wang, Xiuxing, Carcaboso, Angel M., Sloan, Andrew E., Ouyang, Gaoliang, McLendon, Roger E., Bian, Xiu-wu, Rich, Jeremy N., Bao, Shideng
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2017
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206492/
https://ncbi.nlm.nih.gov/pubmed/27923907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151673
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